mitochondria

How to keep your energy chain maintained. Protective compounds.

How to keep your (electron transport) chain-2.png

How to keep your energy chain ( electron transport or ETC) running might not be something you think about, but if you are concerned about being healthier, this is an often overlooked area of maintaining health. It came as a huge disappointment to find out that the historical use of a false tooth compartment to hide cyanide tablets (for soldiers and spies) to commit suicide was pure fantasy. Although cyanide hidden in glasses appears to be more likely, the role of cyanide to induce rapid death is indisputable. We are at a time where industrial pollutants are at an all time high and cyanide being one of those pollutants, might not induce a theatrical foaming of the lips and contorted last throws of life (as seen in many an old war movie); it may induce a slower, less dramatic affect on cell function and efficient biology over time.

Cyanide is certainly ubiquitous in the industrialised environment but unknowingly for many, trying to achieve a ‘healthier’ balanced diet, cyanides are present in many foods favoured by the health conscious.

There are more than 2500 plants associated with cyanide content, these include almonds, millet, lima beans, soy, spinach, bamboo shoots, and cassava roots (which are a major source of food in tropical countries), cyanides occur naturally as part of sugars or other natural compounds. Cassava consumption (especially so in poorer countries) is associated with the neurological, irreversible disease called Konzo (Nzwalo & Cliff, 2011). Some other major sources of cyanide are:

Seeds/kernels of apples, apricots, plums, peach and nectarine, millet, almonds, flax seed, , spinach, sorghum gluten free flour like cassava often used to replace normal flours. Simply type in cassava poisoning into a search engine and you'll see some cases where dozens of people from the same meal have died from a so called bad cassava. Most likely it was the poor preparation and failure to remove the cyanide from the cassava that lead to these numerous deaths. In one case in the Philippines in 2005, 27 children died in such a manner.

Other cyanide sources include vehicle exhaust, releases from chemical industries, burning of municipal waste, and use of cyanide-containing pesticides (Jaszczak et al 2017) and the more obvious smoking.

Excess cyanide (ions) is able to disrupt the efficient production of energy that is produced through the electron transport chain/mitochondria (energy producing cells) where water, carbon dioxide and energy are end products. The loss of this function often creates a decreased ability to utilise carbohydrate effectively and the result can be an excess of lactate, which diminishes cell function further and creates hypoxia. Lactic acid seems to be getting some praise of late but it is the hallmark of inefficient energy production, as observed in the so called Warburg state seen in cancer (5). As cyanide levels increase cellular death occurs through increased lactic acidosis. This is the death throw that you see our actors who have crunched down on that mythical hydrogen cyanide capsule. It's also observed as a cause of death to the unlucky Private Santiago in A Few Good Men, where he has a rag with cleaning fluid, stuffed into his mouth creating a not to dissimilar occurrence.

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You want the truth? You can't handle the truth but it might be that a combination of dietary cyanide and pollutants might not be as healthy as you think.

If there’s a ubiquitous source of cyanide and other pollutants in the environment does it make sense to have plenty of cyanide containing foods? Let’s not take this out of context. Here and there - having foods that have some levels of cyanide in should pose no problem to a healthy individual but what if your diet contains a regular supply and also contains plenty of vegetables that contain goitregens or foods that slow down thyroid function (and also contain cyanide) it may be problematic. Many people seem to promote a diet high in raw green vegetables, nuts, seeds, often low in adequate protein and often deficient in adequate energy/carbohydrate. In this instance the so-called healthy diet, in a highly polluted area becomes a burden not a provider of energy to promote optimal thyroid health, energy and liver enhancer (energy, detox, hormones etc.).

Chris Masterjohn’s report - Thyroid toxins, highlights the out of context suggestions of nutritional science evaluation of compounds in a test tube compared to a real world scenario.

The line that divides nutrients from toxins is often thin and equivocal. Since any given chemical may react in any number of ways in a test tube depending on the other chemicals with which it is combined, it is often possible to prove such a chemical to be both a nutrient and a toxin.

If a diet is to be considered healthy, it should meet the body’s energetic demands without reducing its function. A healthy energy chain ensures that carbohydrate is metabolised efficiently without an excess of lactic acid production.

The abundance of glucosinolates found in broccoli, cauliflower (and other brassica vegetables) and other cyanide like food sources combined with other environmental pollutants may pose substantial problems over time. Heavy metals like mercury, which are also increasing environmentally can decrease selenium and iodine uptake creating another algorithm for decreased function.

cell enhancers

cell enhancers

Caffeine can be considered a useful compound for preventing excess uptake of metals and may go someway to explain the anti-oxidant and other positive effects observed in neurological degeneration diseases such as Alzheimer’s and dementia (Liu et al., 2016). Other compounds like methylene blue can be seen in the next diagram that promote a better energy chain.

" As I have shown in my earlier days , one can knock out the whole respiratory chain by cyanide and then restore oxygen uptake by adding methylene blue  which takes the whole electron transport chain over between dehydrogenases and  O2 ."   Albert Szent Györgi

You can also reduce the risk of excess cyanides in foods through heating, boiling and other forms of processing but given that the zeitgeist is as raw, wholesome and as gluten free as one can be, it’s unlikely that this occurs in the upwardly mobile food neurotic.

References:

  1. Jaszczak, E., Polkowska, Ż., Narkowicz, S., & Namieśnik, J. (2017). Cyanides in the environment—analysis—problems and challenges. Environmental Science and Pollution Research, 24(19), 15929–15948. http://doi.org/10.1007/s11356-017-9081-7

  2. Liu, Q.-P., Wu, Y.-F., Cheng, H.-Y., Xia, T., Ding, H., Wang, H., … Xu, Y. (2016). Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition, 32(6), 628–636. http://doi.org/10.1016/j.nut.2015.11.015

  3. Nzwalo, H., & Cliff, J. (2011). Konzo: From poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease. PLoS Neglected Tropical Diseases. http://doi.org/10.1371/journal.pntd.0001051

  4. Masterjohn, C. Thyroid Toxins Report. 2007

  5. http://raypeat.com/articles/articles/cancer-disorder-energy.shtml

  6. Szent Györgi, A. Introduction to a Submolecular Biology. Academic Press. 1960.

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Methylene Blue - Let’s play the blues.

Methylene blue - an overview: There’s been many times when I have recommended compounds/agents to create change in clients. Even the basic strategies of increasing sugar, not wearing sunscreen or the use of aspirin for improving energy and decreasing oxidative stress has moved the odd eyebrow to be raised. Objections often dissipate when presented with the line of reasoning and research that supports my recommendations. Effective clients will often do their own research and come back armed with significant questions for a better understanding of what is trying to be achieved. Research previously conducted by the Nobel scientist Albert Szent Györgi showed that previously damaged cells that produce efficient energy can be restored with methylene blue.

MB.jpg

Restoring respiration with colour.

So with the tradition of raising more eyebrows let’s suggest the use of a blue dye that can be added to aquariums for improving marine life health. That’s right you put it in fish tanks. Why indeed would you not think of consuming glassfuls of the stuff?

Methylene blue (MB) is a dye that has shown promising results in the following areas:

  • Tissue hypoxia

  • Hyper dynamic circulation of the liver post cirrhosis

  • Improved low blood pressure states

  • Hepato-pulmonary syndrome

  • Anti malarial agent

  • Improves mitochondrial function

  • Detects parasites such as h-Pylori

  • With additional treatment of red light has anti-parasitic effects.

  • Anti-microbial-kills MRSA

  • Hepatitis C and other conditions also effectively treated in tandem with red light application.

  • Anti-Alzheimer’s agent- attenuates amyloid plaques and improves mitochondrial function.

MB is able to decrease both nitric oxide and guanylate cyclase, both exert their influence on smooth cells and tissue, explaining its role in reversing severely low blood pressure states ( Medically termed - catecholamine refractory vasoplegia)

If we look closely at a couple of the major mechanisms, we can see that from a metabolic standpoint MB has some interesting benefits. It decreases hypoxia or increases oxygen saturation within the body, whilst also improving mitochondrial energy production.

The respiratory/ electron transfer (ETC) chain, that is essentially the mechanism providing optimal use of oxygen, carbohydrate, fat, when this functions well, carbon dioxide is produced, which allows for optimal dissociation of oxygen from haemoglobin. When the respiratory chain is damaged, cells often have to switch to inefficient anaerobic sources of energy production, wasting sugar and increasing lactic acid, which continue to decrease aspects of cellular function.

Methemoglobinemia is a state where haemoglobin is unable to carry oxygen. MB reacts within the red blood cell and converts ferric ions, which have been oxidised, to its former oxygen carrying state. Additionally it helps to repair the ETC that is often damaged due to pollutant, poison or inefficient metabolic induced changes as seen in states of Alzheimer’s (Oz, Lorke, & Petroianu, 2009).

Another novel aspect of MB is the treatment of parasitic infection. MB absorbs and reacts with the spectrum of red light acting as an antimicrobial/parasitic agent.

“ Protozoa require the invasion of a suitable host to complete all or part of their life cycle.”

So what constitutes an appropriate host? I offer the following definition.

An individual or organism that is unable to assimilate and produce energy effectively, organise optimal cellular function and provide an immune response capable of expelling or eradicating an opportunistic parasitic/bacterial infection.

I quote Ray Peat with the following:

“ Occasionally you have very vigorous parasites that have intentions. If they encounter you in a state when your blood sugar is low, for example, the parasites might find an opportunity and start disorganising your system. So the competing systems’ lower system getting a foothold in a higher system, counts as randomness. The assumption of randomness is usually that everything is always random. What has been ordered is achieved at a high cost, the arrow of time for these people is that you have to expend energy to create order, and get things piled up in a certain way can only do that by expending energy somewhere else. "

MB and the use low level laser therapy (or LLLT which uses red or near infra red light) have a commonality with their ability to reduce the inhibitory actions of nitric oxide. This leads to enhanced cytochrome c oxidase action at complex IV of the ETC ( in English this means the enzyme that promotes better function of the cells that use oxygen efficiently), promoting increased cellular respiration and energy production (ATP). These dual actions appear to be an effective anti-parasitic treatment.

If your still running around taking a rucksack full of supplements, restricting energy and immune enhancing foods to kill parasites and candida, this may be a far more effective therapy to consider. It should be no surprise that that considering these actions, the use of MB is being investigated as a serious therapy in the fight against cancer. The biology of cancer can be attributed to metabolic defects/damage within the mitochondria leading to mutations.

Of course like any compound whether it be oxygen, water, broccoli or vodka certain doses are problematic. However these are generally high. For example doses used to treat malaria are suggested as 36-72mg/kg over 3 days (Meissner et al., 2006) and safe therapeutic doses are suggested as <2mg/kg (Ginimuge & Jyothi, 2010). Newborn babies seem susceptible to MB side effects such as skin discoloration, respiratory distress and other unwanted symptoms. However, the mechanisms of why this might happen, requires a blog alone. It also appears problematic to those taking SSRI’s and can increase serotonin uptake to toxic levels.

What I have learnt from taking MB.

I found that if I took doses of more than 5mg total within a day or two of each other, my urine turned blue. A self -limiting factor that probably suggests that I was taking too much. I also had the odd crazy dream. I generally found that a total intake of 2.5 mgs or around 5 drops 2-3 days per week seemed to serve me well. I titrated up and found the optimal dose, something which I strongly recommend doing for all.

I found that my pulse oximeter readings improved from a general SpO2 93-97 to regular 98. Which is interesting as one side effect previously suggested is the ability of MB to underestimate pulse ox readings. It’s prudent to imply that any therapeutic dose may only create change as the system allows. Therefore basics strategies such as effective blood sugar regulation, through regular eating and other strategies should be applied.

Ps it’s also great at reversing cyanide and nitrate poisoning in fish. Might it be useful in humans consuming too much bacon?

1. Ginimuge, P. R., & Jyothi, S. D. (2010). Methylene blue: revisited. Journal of Anaesthesiology, Clinical Pharmacology, 26(4), 517–20.

2. Meissner, P. E., Mandi, G., Coulibaly, B., Witte, S., Tapsoba, T., Mansmann, U., … Müller, O. (2006). Methylene blue for malaria in Africa: Results from a dose-finding study in combination with chloroquine. Malaria Journal, 5. http://doi.org/10.1186/1475-2875-5-84

3. Oz, M., Lorke, D. E., & Petroianu, G. A. (2009). Methylene blue and Alzheimer’s disease. Biochemical Pharmacology, 78(8), 927–932. http://doi.org/10.1016/j.bcp.2009.04.034

4. Ray Peat quote originally taken from a YouTube interview with Andrew Murray. (cant recall which one)

5. https://www.google.com/patents/WO2007038201A1?cl=en 6. http://valtsus.blogspot.ae/ contains over 2500 LLLT studies and is by far the best resource available on the actions of LLLT.

Why are polyunsaturated fats and oils so dangerous?

Polyunsaturated fats/ fatty acids or PUFAs have been suggested as being a safe food source for many years and many have even touted as being protective for the heart. Saturated fats have been outcast as the villain as the marketing purse of seed manufacturers often outweighed the gain that could be had by the protective more stable fats of coconut and palm oils.

Because the molecular structure of PUFA’s are less stable than saturated fats when heated they become carcinogenic.  Many studies favoured by the seed industry have favoured the analysis of so called good and bad cholesterol or LDL’s and HDL’s as a marker for the so called healthy effect of vegetable and seed oils.  A factor overlooked as part of this education is that high HDL levels can be interpreted as an auto immune process in action and cancerous states can be correlated with high HDL levels.  Heat alone will not cause PUFA’s to become unstable, overtime these oils can become rancid and when consumed cause lipid peroxidation . Think of all those warehouses of nuts that have been sitting around for months or years before being consumed, which are then often roasted and the PUFA’s within them oxidised.

The problem is that when all of these oils are consumed they cause the production of Reactive Oxygen Species or ROS and lipid peroxidation which causes large amounts of stress to cellular DNA which can be responsible for genetic mutations which can lead to aging, cell destruction and cancers. Ray Peats work on the damage caused by PUFA’s is very well documented.

Many commercially consumed foods such as tortilla chips (which mostly are derived from genetically engineered crops that have been covered in harmful pesticides) have been fried in these oils causing a dabble whammy of oxidative stress and insult to the human organism. People often think that by eating healthily they are able to not worry about small details such as fats and have often been falsely convinced that butter/ghee/ coconut and palm oils and that, high fat diets are the causative link in heart disease and heart attacks.

From a skin health perspective, unstable fats such as PUFA in the skin may be problematic when exposed to excess amounts of ultraviolet light. This recent blog explains the mechanisms.

Dealing with ridding the body of dangerous PUFA’s stored in body fat stores can be achieved with the right diet plan and ameliorating the dangerous effects of lipid peroxidation can be achieved with supplementation such as Vitamin E, B’s,  Asprin  and others.   Below I have highlighted a list of oils  that are ideal for cooking with and the others should be avoided.  To find out more about restoring your body to optimal health please get in touch. Balanced Body Mind

Approximate polyunsaturated fats/fatty acids- PUFA content of various oils and fats:  (taken fromIntegrative/med)

Evening Primrose oil (81% PUFA) Hemp oil (80% PUFA) Flax oil (72% PUFA) Grapeseed oil (71% PUFA) Chia oil (70% PUFA) Safflower oil (75% PUFA) Sunflower oil (65% PUFA) Perilla oil (63% PUFA) Corn oil (59% PUFA) Soybean oil (58% PUFA) Pumpkin oil (57% PUFA) Walnut oil (55-63% PUFA) Cottonseed oil (50% PUFA) Sesame oil (41-45% PUFA) Canola oil (30-37% PUFA) Rice bran oil (36% PUFA) Beech nut oil (32% PUFA) Peanut oil (29-32% PUFA) Pecan oil (29% PUFA) Brazil nut oil (24-36% PUFA, 24% SAFA) Pistachio oil (19% PUFA) Cashew oil (17% PUFA, 20% SAFA) Almond oil (17% PUFA, 8% SAFA) Duck fat (13% PUFA, 1% cholesterol)                 Use but try to go for safer oils below Lard (12% PUFA, 41% SAFA, 1% cholesterol)  Use but try to go for safer oils below Filbert oil (10-16% PUFA) Avocado oil (10% PUFA) Macadamia oil (10% PUFA, 15% SAFA)

Safe cooking oils Goose fat (10% PUFA, 1% cholesterol) Palm oil (8% PUFA, 50% SAFA) Olive oil (8% PUFA, 14% SAFA) Butter (4% PUFA, 50% SAFA) Ghee (4% PUFA, 48% SAFA, 2% cholesterol) Cocoa Butter (3% PUFA, 60% SAFA) Coconut oil (2-3% PUFA, 92% SAFA, 0% cholesterol) Palm kernel oil (2% PUFA, 82% SAFA)